PUBLICATIONS
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Chakraborty S, Mallick D, Goswami M, Chakrabarty A, Guengerich FP and Chowdhury G*. The Natural Products Withaferin A and Withanone From the Medicinal Herb Withania somnifera are Covalent Inhibitors of the SARS-CoV-2 Main Protease. J. Nat. Prod. 2022, 85, 2340-2350. Cover Page Article
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A, Chakraborty S, Bhattacharya R, and Chowdhury G. Senescence-Induced Chemoresistance in Triple Negative Breast Cancer and Evolution based Treatment Strategies. Front. Oncol. 24 June, 2021S
Siddiqui S, Ahmed N, Goswami M, Chakrabarty A and Chowdhury G. DNA Damage by Withanone as a Potential Cause of Liver Toxicity Observed for Herbal Products of Withania somnifera (Ashwagandha). Curr. Res. Toxicol. 2021, 2, 72-81
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Wani TH, Chowdhury G and Chakrabarty A*. Generation of Reactive Oxygen Species is the Primary Mode of Action and Cause of Survivin Suppression by Sepantronium Bromide (YM155). RSC Med. Chem. 2021, 12, 566-578
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Ahmed N, Chakrabarty A, Guengerich FP and Chowdhury G* Protective Role of Glutathione Against Peroxynitrite-Mediated DNA Damage During Acute Inflammation. Chem. Res. Toxicol. 2020, 33, 2668-2674
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Chakrabarty A*, Surendran S, Bhola, NE, Mishra VS, Wani TH, Khemraj SB, Arteaga CL, Garg R, Chowdhury G. The H1047R PIK3CA oncogene induces a senescence-like state, pleiotropy and acute HSP90 dependency in HER2+ mammary epithelial cells. Carcinogenesis 2019, 40, 1179-1190
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Wani TH, Surendran S, Mishra VS, Chaturvedi J, Chowdhury G, and Chakrabarty A*. Adaptation to chronic exposure to sepantronium bromide (YM155), a prototypical survivin suppressant is due to persistent DNA damage-response in breast cancer cells. Oncotarget 2018, 9 (71), 33589
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Wani TH, Suendran S, Jana A, Chakrabarty A, and Chowdhury G*. The Quinone Based Antitumor Agent Sepantronium Bromide (YM155) Causes Oxygen Independent Redox Activated Oxidative DNA Damage. Chem. Res. Toxicol. 2018, 31(7), 612-618 Cover Page Article
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Wani TH, Chakrabarty A, Shibata N, Yamazaki H, Guengerich FP, and Chowdhury G*. The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage. Chem. Res. Toxicol. 2017, 8, 1622-1628
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Chowdhury G*, and Guengerich FP. Mass Spectrometry of Nucleic Acids. Encyclopedia of Analytical Chemistry. 2015, John Wiley & Sons, Ltd. DOI: 10.1002/9780470027318.a1416.pub2
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Chowdhury G*. and Guengerich FP. Characterization of Thioether-Linked Protein Adducts of DNA Using a Raney-Ni-Mediated Desulfurization Method and Liquid Chromatography-Electrospray-Tandem Mass Spectrometry.Curr. Protoc. Nucleic Acid Res. 2015, 60:10.15.1-10.15.14. DOI: 10.1002/0471142700.nc1015s60.
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Chowdhury G and Guengerich FP. Liquid Chromatography-Mass Spectrometry Analysis of DNA Polymerase Reaction Products. Curr. Protocols Nucleic Acids Res. 2011, Chapter 7:Unit 7.16, 1-11.
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Chowdhury G, Shibata N, Yamazaki H and Guengerich FP. Human Cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analog of thalidomide. Chem. Res. Toxicol. 2014, 27, 147-56.
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Chowdhury G, Cho SH, Pegg A and Guengerich FP. Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6)-alkylguanine-DNA alkyltransferase. Angew. Chem. Intl. Ed. 2013, 52, 12879-82. This paper was selected as a very important paper in Angew. Chem. Intl. Ed and also reviewed in Chembiochem
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Bajpai P, Sangar MC, Singh S, Tang W, Bansal S, Chowdhury G, Cheng Q, Fang JK, Martin MV, Guengerich FP, Avadhani NG. Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease. J. Biol Chem. 2013, 288, 4436-51.
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Chowdhury G, Calcutt MW, Nagy LD, Guengerich FP. Oxidation of methyl and ethyl nitrosamines by cytochrome P450 2E1 and 2B1. Biochemistry 2012, 51, 9995-10007.
Yamazaki H, Suemizu, H.; Shimizu M, Igaya S, Shibata N, Nakamura M, Chowdhury G, Guengerich FP. In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice. Chem. Res. Toxicol. 2012 25, 274-276.
Chowdhury G, Sarker U, Pullen S, Wilson WR, Rajapakse A, Fuchs-Knotts T and Gates KS. DNA damage by the naturally-occurring heterocyclic N-oxide myxin under both aerobic and anaerobic conditions. Chem. Res. Toxicol. 2012, 25, 197-206.
Yamazaki H, Suemizu H, Igaya S, Shimizu M, Shibata N, NakamuraM, Chowdhury G and Guengerich FP. In vivo Formation of a Glutathione Conjugate derived from Thalidomide in humanized uPA-NOG mice. Chem. Res. Toxicol. 2011, 21, 287-289.
Chowdhury G, Murayama N, Okada Y, Uno Y, Shimizu M, Guengerich FP, and Yamazaki H. Human Liver Microsomal Cytochrome P450 3A Enzymes Involved in Thalidomide 5-Hydroxylation and Formation of a Glutathione Conjugate. Chem. Res. Toxicol. 2010, 23, 1018-1024. (first two authors have equal contribution)
Christov PP, Chowdhury G, Garmendia CA, Wang F, Stover J, Elmquist CE, Kozekova A, Angel KC, Turesky RJ, Stone MP, Guengerich FP and Rizzo CJ. The C8-2'-Deoxyguanosine Adduct of 2-Amino-3-methylimidazo[1,2-d]naphthalene, a Carbocyclic Analogue of the Potent Mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ), is a Block to Replicationin Vitro. Chem. Res. Toxicol. 2010, 23, 1076-1088. (first two authors have equal contribution)
Chowdhury G, Calcutt MW and Guengerich FP. Oxidation of N-Nitrosoalkylamines by human cytochrome P450 2A6. J. Biol. Chem. 2010, 285, 8031-8044. (first two authors have equal contribution)
Chowdhury G, Dostalek M, Hsu E, Nguyen LP, Bradfield CA and GuengerichFP. Structural identification of diindole Ah receptor agonists derived from degradation of indole-3-pyruvic acid. Chem. Res. Toxicol. 2009, 22, 1905-1912. (first two authors have equal contribution)
Nguyen LP, Hsu E, Chowdhury G, Dostalek M, GuengerichFP and Bradfield CA. D-Amino acid oxidase generates agonists of the aryl hydrocarbon receptor from D-tryptophan. Chem. Res. Toxicol. 2009, 22, 1897-1904.
Chowdhury G, and Guengerich FP. Tandem Mass Spectrometry-based Detection of C4¢-Oxidized Abasic Sites at Specific Positions in DNA Fragments. Chem. Res. Toxicol. 2009, 22, 1310-1319.
Fang Q, Noronha AM, Murphy SP, Wilds CJ, Tubbs JI, Tainer JA, Chowdhury G, GuengerichFP and Pegg AE. Repair of O6-G-alkyl-O6-G interstrand cross-link by human O6-alkylguanine-DNA alkyltransferase. Biochemistry 2008, 47, 10892-10903.
Chowdhury G, and Guengerich FP. Direct detection and mapping of sites of modifications in DNA by tandem mass spectrometry. Angew. Chem. Int. Ed. 2008, 47, 381-384.
Chowdhury G, Junnutula V, Daniels JS, Greenberg MM and Gates KS. DNA strand damage product analysis provides evidence that the tumor cell-specific cytotoxin tirapazamine produces hydroxyl radical and acts as a surrogate for O2. J. Am. Chem. Soc. 2007, 129, 12870-12877.
LaButti J, Chowdhury G, Reilly T and Gates KS. Redox regulation of protein tyrosine phosphatase 1B (PTP1B) by peroxymonophosphate (=O3POOH). J. Am. Chem. Soc. 2007, 29, 5320-5321.
Dutta S, Chowdhury G, and Gates KS. Interstrand crosslinks generated by abasic sites in duplex DNA. J. Am. Chem. Soc. 2007, 129, 1852-1853.
Choi J.-Y, Chowdhury G, Zang H, Angel KC, Vu CC, Peterson LA and Guengerich FP. Translesion synthesis across O6-alkylguanine DNA adducts by recombinant human DNA polymerases. J. Biol. Chem. 2006, 281, 38244-38256. (first two authors have equal contribution)
Stover JS, Chowdhury G, Zang H, Guengerich FPand Rizzo CJ.Translesion synthesis past the C8- and N2-deoxyguanosine adducts of the dietary mutagen 2-amino-3-methylimidazole[4,5-f] quinoline (IQ) in the NarI recognition sequence by bacterial polymerases. Chem. Res. Toxicol. 2006, 19, 1506-1517.
Choi J-Y, Stover JS, Angel KC, Chowdhury G, Rizzo CJ and Guengerich FP. Biochemical basis of heterocyclic arylamine food mutagens: Human DNA polymerase h selectively produces a two-base deletion in coping the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8-adduct at the NarI G3 site. J. Biol. Chem. 2006, 281, 25297-25306.
Zang H, Chowdhury G, Angel KC, Harris TM, and Guengerich FP. Translesion synthesis across polycyclic aromatic hydrocarbons diol epoxide adducts of deoxyadenosine by Sulfolobussolfataricus DNA polymerase Dpo4. Chem. Res. Toxicol. 2006, 19, 859-867.
Chowdhury G, Kotandeniya D, Daniels JS, Barnes C and Gates KS. Enzyme-activated, hypoxia selective DNA cleavage by 3-amino 2-quinoxalinecarbonitrile 1,4-di-N-oxide. Chem. Res. Toxicol. 2004, 17, 1399-1405.
Birincioglu M, Jaruga P, Chowdhury G, Rodriguez H, Dizdaroglu M and Gates KS. DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine). J. Am. Chem. Soc. 2003, 125, 11607-11615.
Chatterji T, Kizil M, Keerthi K, Chowdhury G, Posposil J and Gates KS. Small molecule that mimic the alkylating properties of the natural product leinamycin. J. Am. Chem. Soc. 2003, 125, 4996-4997.
Poole JS, Hadad CM, Platz MS, Fredin ZP, Pickard L, Guerrero EL, Kessler M, Chowdhury G, Kotandeniya D and Gates KS. Photochemical electron transfer reactions if tirapazamine. Photochem. Photobiol. 2002, 75, 339-345.
Ganley B, Chowdhury G, Bhansali J, Daniels JS and Gates KS. Redox activated hypoxia-selective DNA cleavage by quinoxaline 1,4-dioxide. Bioorg. Med. Chem. 2001, 9, 2395-2401.
Fuchs TE, Chowdhury G, Barnes CL and Gates KS. 3-amino-1,2,4-benzotriazine 4-oxide: Characteristics of a new metabolite arising from bioreductive processing of the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine). J. Org. Chem. 2000, 66, 107-104.
Guengerich FP, Sohl CD and Chowdhury G. Multistep oxidations catalyzed by cytochrome P450 enzymes: Processive vs. distributive kinetics and the issue of carbonyl oxidation in chemical mechanisms. Arch. Biochem. Biophys. 2011, 507, 126-134.